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AUTHOR(S): Jose Manuel Lopez-Guede, Iñigo Aramendia, Unai Fernandez-Gamiz, Javier Sancho, Miguel Angel Gomez Solaetxe, Alberto Lopez-Arraiza, Francisco Jose Basterretxea
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KEYWORDS Respiratory Distress Syndrome, Aerodynamic Particle Sizer, Inhalation catheter, aerosol |
ABSTRACT Respiratory Distress Syndrome (RDS) of the newborn is the leading cause of death in premature infants. The current surfactant replacement therapy presents some drawbacks, as it requires the intubation of the newborn and the application of mechanical ventilation, which may induce lung injuries and/or chronic diseases. The upsurge use of non-invasive ventilation techniques in preterm babies, as CPAP, has led to the study of new minimally invasive surfactant therapies. In this paper an inhalation catheter (IC) (AeroProbe, Trudell Medical International), with one central lumen to deliver the liquid and six peripheral lumens to deliver the compressed air, has been tested to study the aerosol generated both experimentally and numerically. An Aerodynamic Particle Sizer (APS 3321, TSI Incorporated) has been used, which provides high-resolution, real-time aerodynamic measurements of particles from 0.5 to 20 µm. Additionally, Computational Fluid Dynamics (CFD) techniques have been used in order to develop a mathematical model to characterize the aerosol generated by the IC. |
Cite this paper Jose Manuel Lopez-Guede, Iñigo Aramendia, Unai Fernandez-Gamiz, Javier Sancho, Miguel Angel Gomez Solaetxe, Alberto Lopez-Arraiza, Francisco Jose Basterretxea. (2017) Characterization of Aerosol Delivery for Preterm Infants. International Journal of Medical Histology and Embryology, 1, 1-7 |
