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AUTHOR(S): Shania Srivastav, Alpa Raval, Abhijit S. Pandya
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ABSTRACT This project looks at how diet changes may affect inflammation in the nervous system, using the nematode Caenorhabditis elegans as a model. The goal was to explore whether nutrients such as fats, vitamins, and plant compounds can alter brain-related processes like those seen in neurodegenerative diseases. The hypothesis was that altering metabolism through diet would lead to measurable changes in inflammation and behavior. To test this, worms were given food supplemented with omega-3 fatty acids, vitamin E, or curcumin, and their movements were tracked through thrashing and locomotion assays. Interestingly, worms exposed to omega-3 moved slightly less than the control group, and those that received vitamin E showed a clearer reduction in activity. Curcumin caused a moderate effect that fell between the two. These patterns suggest that diet can meaningfully shape how the nervous system reacts to inflammation. In short, nutrition seems to play a major role in linking metabolism with neural function. What we learn from these simple organisms might help clarify how diet affects brain health in humans, where inflammation and nutrition are deeply connected. |
KEYWORDS C. Elegans, Curcumin, Omega-3, Vitamin E, Behavior, Thrashing, Neuroinflammation, Locomotive |
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Cite this paper Shania Srivastav, Alpa Raval, Abhijit S. Pandya . (2025) Metabolic Modulation of Neuroinflammatory Responses and Behavior of Caenorhabditis Elegans: Implications for Neuronal Resilience and Function. International Journal of Biology and Biomedicine, 10, 73-78 |
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