Effect of Antiretroviral Therapy on CD4+/CD8+ Ratio in HIV Patients in Immune Recovery Stages at a Tertiary Care Hospital in Riyadh

AUTHOR(S):

Abdulhadi Alqahtani, Mohammed Altuwaijri, Amjad Haddad, Samera Al-Johani, Abdullah Al-Qouzi, Fayzah Aldugaishm, Humariya Heena, Dunia Jawdat, Raed M. Kana

TITLE

Effect of Antiretroviral Therapy on CD4+/CD8+ Ratio in HIV Patients in Immune Recovery Stages at a Tertiary Care Hospital in Riyadh

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ABSTRACT

This HIV infection is not a common in Saudi Arabia. The enumeration of CD4+ and CD8+ remains a fundamental method to measure HIV disease progression, and the CD4+/CD8+ ratio is a reflection of the immune system’s health. The aim of this study was to determine the effect of antiretroviral therapy on the CD4+/CD8+ ratio in patients suffering from HIV infection in Saudi Arabia. Retrospective data of thirty HIV cases were collected from the electronic medical records in a tertiary care hospital in Riyadh (King Abdul-Aziz Medical City) during 2005-2012. The number of CD4+ and CD8+ cells by flow Cytometry technique was studied for each patient over several visits. The viral load measured by PCR, antiretroviral therapy data was documented for these patients and the data analyzed by parametric data analysis using the appropriate statistical software. Our results showed that 40% of the patients had improved CD4+/CD8+ ratio after ART therapy. 17% of these patients maintained a constant rate and 43% had a severe drop in the CD4+/CD8+ ratio. Our finding showed that using the CD4+/CD8+ ratio is useful to determine the disease progression and the effectiveness of ART therapy. However, more studies are needed with a large number of patients to support our findings

KEYWORDS

HIV, AIDS, Infection, CD4+, CD8+, CD4+/CD8+, antiretroviral therapy

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Cite this paper

Abdulhadi Alqahtani, Mohammed Altuwaijri, Amjad Haddad, Samera Al-johani, Abdullah Al-qouzi, Fayzah Aldugaishm, Humariya Heena, Dunia Jawdat, Raed M. Kanan. (2018) Effect of Antiretroviral Therapy on CD4+/CD8+ Ratio in HIV Patients in Immune Recovery Stages at a Tertiary Care Hospital in Riyadh. International Journal of Biology and Biomedicine, 3, 22-25