Complexes of Lysine Dendrimers of 2nd Generation with Semax and Epithalon Peptides. Molecular Dynamics Simulation

AUTHOR(S):

Igor M. Neelov, Elena V. Popova, Dilorom N. Khamidova, Irina I. Tarasenko

TITLE

Complexes of Lysine Dendrimers of 2nd Generation with Semax and Epithalon Peptides. Molecular Dynamics Simulation

ABSTRACT

Dendrimers are widely used as vehicles for drug and gene delivery. In present study complexes of lysine dendrimer of second generation and two types of therapeutic regulatory peptides (Semax and Epithalon) were investigated. Two systems containing lysine dendrimer and 16 oppositely charged model peptides (Semax or Epithalon) were simulated using full atomic models and molecular dynamics method. Both complex formation and equilibrium properties of complexes were studied. It was obtained that dendrimer forms complexes with both peptides very quickly and the sizes and the structures of complexes are very close to each other. These or similar complexes could be used in future for delivery of different therapeutics peptides to patients body.

KEYWORDS

Lysine dendrimer, Semax, Epithalon, Complex, Molecular dynamics simulation

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Cite this paper

Igor M. Neelov, Elena V. Popova, Dilorom N. Khamidova, Irina I. Tarasenko. (2017) Complexes of Lysine Dendrimers of 2nd Generation with Semax and Epithalon Peptides. Molecular Dynamics Simulation. International Journal of Biochemistry Research, 2, 28-33