AUTHOR(S): 

Igor Neelov, Elena Popova

TITLE

Interaction of Lysine Dendrimer and Semax Peptides. Molecular Dynamics Simulation

KEYWORDS

lysine dendrimer, Semax peptides, computer simulation, molecular dynamics

ABSTRACT

Interaction between lysine dendrimer and therapeutic Semax peptides was investigated using molecular dynamics method. Dendrimers were used for drug and other molecules delivery to different cells. It was shown earlier that dendrimers and in particular lysine dendrimers could penetrate blood brain barrier. In present paper we study three systems containing such dendrimer and 8, 16 or 24 oppositely charged Semax peptides. It was obtained that lysine dendrimer attracts Semax peptides and forms stable complexes with them. The sizes and structures of these complexes were investigated. These complexes can be used in future for delivery of Semax peptides to brain since these peptides have significant neuroprotective effects.

Cite this paper

Igor Neelov, Elena Popova. (2017) Interaction of Lysine Dendrimer and Semax Peptides. Molecular Dynamics Simulation. International Journal of Biology and Biomedicine, 2, 6-12